cannabis

Five patients experienced very unpleasant psychic effects after 9-THC; three patients said they felt as if they were dying, one patient experienced depressed mood, and one patient suffered paranoid ideation. In two patients, the adverse mood effects persisted 3 or 4 days or cannabis seeds. These studies indicate that 9-THC has some analgesic activity in humans. They also indicate that there is, at best, a very narrow therapeutic window between doses that produce useful analgesia and those that produce unacceptable adverse CNS effects. 2. What are the major unanswered scientific questions?